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Objective To describe the Xinjiang region of tuberculous meningitis (TBM) (age ＞ 18 years of age) in patients with the clinical features,analysis of factors influencing the prognosis.Methods A retrospective of cases included in the data collection,describe the clinical characteristics,using the single factor and multiple factors Logistic regression analysis of factors influencing the prognosis.Results A total of 200 cases of TBM patients had the following characteristics:120 cases of male,female 80 cases;age 18 -75 (37.35 ±+ 14.24) years old;the course of the disease 3-270 (36.86 +43.86)days;and 179 cases of survival,21 cases of death,with a mortality of l0.5％.Single factor analysis showed that hydrocephalus,encephaledema,clinical staging,erythrocyte sedimentation rate,cerebro-spinal fluid (CSF)-protein had statistically significant difference between survival group and death group,respectively (P ＜ 0.05).The multi-factor Logistic regression analysis showed that encephaledema and erythrocyte sedimentation rate were independent factors to affect the prognosis of TBM (P ＜ 0.05).Conclusions Encephaledema and erythrocyte sedimentation rate are independent risk factors of poor prognosis in patients with TBM,early identify predictors,formulate corresponding clinical countermeasures,and can improve the prognosis of patients with tuberculous meningitis.
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Objective A retrospective analysis was carried out for the classification and character-istics of fever of unknown origin, and its trend in recent years. Methods A total of 1192 patients with fe-ver of unknown origin, who were admitted to the First Affiliated Hospital of Xinjiang Medical University from January 2010 to December 2016, were enrolled in this study. Descriptive analysis of the proportion, charac-teristics, and trend different diseases in the fever of unknown origin was performed. Results A total of 1080 cases was diagnosed in 1192 patients, with a diagnosis rate of 90. 6％. The final diagnoses included infections, inflammatory diseases, malignancies and miscellaneous conditions in 72. 9％, 9. 1％,5. 1％ and 3. 4％ of subjects, whereas 9. 4％ of cases remained undiagnosed. The results of variance analysis showed that the white blood cells and hemoglobin of infectious diseases were higher than those of connective tissue disease and malignancy were respectively [(11. 12 ± 2. 58) × 109/L vs (8. 82 ± 1. 12) × 109/L vs (9. 67 ±2.76) ×109/L, (116.81 ±20.77)g/L vs (103.25 ±22.84)g/L vs (102.30 ±25.14)g/L], While period of hospitalization and erythrocyte sedimentation rate were lower than that of connective tissue disease and malignancy were respectively [ ( 12. 15 ± 7. 91 ) days vs ( 19. 94 ± 10. 17 ) days vs ( 18. 85 ± 14. 37 ) days, (48.12 ±20.93)mm/h vs (58.13 ±20.24)mm/h vs (56.9 ±20.52)mm/h], and the age of ma-lignant was higher than that of infectious disease and connective tissue disease were [(56. 38 ± 17. 57)years vs (45. 99 ± 16. 79)years vs (41. 09 ± 16. 79)years], the difference was statistically significant (P<0. 05).The rank sum test showed that eosinophils, lymphocytes and interleukin-6 were not equal ( P <0. 05 ) . Conclusions Infectious diseases in fever of unknown origin ( FUO) are still the main cause. whereas blood cells, eosinophils, lymphocytes, hemoglobin,erythrocyte sedimentation rate, interleukin 6, age and hospi-talization time were predictive of disease diagnosis. In recent years, there was no obvious trend of all kinds of diseases.
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Objective To investigate the clinical indicators which can predict esophageal varices in patients with primary biliary cirrhosis (PBC).Methods A total of 351 patients with PBC from the First Affiliated Hospital of Xinjiang Medical University from January 2013 to December 2016 were retrospectively analyzed, including 173 patients with esophageal varices and 178 patients without varicose veins.The alanine aminotransferase (ALT), aspartate transaminase (AST), alkaline phosphatase (ALP), γ-glutamyl transpeptadase (γ-GT), total bilirubin (TBil), albumin (Alb), prothrombin time (PT), platelet (PLT), AST to ALT ratio (AAR), fibrosis index based on the 4 fator (FIB-4), AST to PLT ratio index (APRI) and Mayo scores were compared between two groups.Group t test or rank sum test was used to compare the two groups.Relation between the indicators mentioned above and esophageal varices were tested by univariate analysis.Multivariate unconditional Logistic regression was used to screen these indicators to independently predict esophageal varices in PBC patients.Results Age, PT, TBil, AAR, FIB-4, APRI and Mayo scores of PBC patients with esophageal varices were all higher than those of patients without esophageal varices ([60.3±10.6] years old vs [51.9±10.9] years old, [13.31±3.12] s vs [11.17±2.42] s, 28.06 [18.05, 60.06] mmol/L vs 15.39 [10.64, 33.63] μmol/L, 1.69±0.91 vs 1.23±0.95, 6.18 [4.05,9.16] vs 1.80 [1.10,2.74], 1.95 [1.12,3.08] vs 0.69 [0.38,1.57], 6.45±1.52 vs4.62±1.53, respectively).Whereas ALT, γ-GT, Alb and PLT levels were all lower than those without varicose veins (36.60 [19.88, 74.28] U/L vs 59.32 [23.58, 132.70] U/L, 71.00 [38.36, 165.38] U/L vs 125.00 [37.50, 336.21] U/L, [29.78±6.33] g/L vs [39.51±25.16] g/L, [103.43±52.84]×109/L vs [234.44±90.40]×109/L, respectively).The differences were all statistically significant (t=-7.25, t=-7.18, Z=-5.823, t=-4.60, Z=-8.427, Z=-12.661, t=-11.25, Z=-3.218, Z=2.987, t=4.94, t=16.63, respectively;all P11.95 s (OR=0.705, 95%CI: 0.569-0.874), TBil>17.19 μmol/L (OR=0.99, 95%CI: 0.982-0.999), FIB-4>3.02 (OR=0.868, 95% CI: 0.807-0.932) and Mayo score>4.88 (OR=6.053, 95%CI: 2.388-15.342) were independent clinical indicators for the prediction of esophageal varicose veins.Conclusions PLT, PT, TBil, FIB-4, and Mayo scores can be used as predictors of esophageal varices in patients with PBC.